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Santiago Castanys Selected Research

8-aminoquinoline

9/2011The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase.
8/2011Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.
3/2011Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major.
12/2010Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis.

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Santiago Castanys Research Topics

Disease

8Neoplasms (Cancer)
03/2016 - 10/2004
7Visceral Leishmaniasis (Kala Azar)
01/2016 - 08/2003
6Leishmaniasis
04/2015 - 09/2006
3Malaria
03/2011 - 10/2007
2Carcinoma (Carcinomatosis)
09/2010 - 02/2008
2Infections
09/2007 - 06/2003
2Breast Neoplasms (Breast Cancer)
06/2005 - 10/2004
1Parasitic Diseases (Parasitic Disease)
01/2016
1Mitochondrial Diseases (Mitochondrial Disease)
12/2010
1Cutaneous Leishmaniasis
04/2009

Drug/Important Bio-Agent (IBA)

10Pharmaceutical PreparationsIBA
01/2016 - 08/2003
8miltefosine (Impavido)IBA
01/2016 - 08/2003
48-aminoquinolineIBA
09/2011 - 12/2010
3Member 1 Subfamily B ATP Binding Cassette TransporterIBA
03/2016 - 10/2004
3Proteins (Proteins, Gene)FDA Link
06/2005 - 06/2003
2N(1)-methyl-2-lysergic acid diethylamide (MIL)IBA
01/2016 - 12/2003
2Drug CombinationsIBA
04/2015 - 01/2012
2tafenoquineIBA
03/2011 - 12/2010
2perifosineIBA
09/2010 - 02/2008
2Adenosine Triphosphate (ATP)IBA
10/2008 - 02/2008
2Antineoplastic Agents (Antineoplastics)IBA
08/2006 - 12/2003
1Heme (Haem)IBA
03/2011
1Cytochromes c (Cytochrome c)IBA
12/2010
1Oxidoreductases (Dehydrogenase)IBA
12/2010
1PrimaquineFDA Link
12/2010
1Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA
12/2010
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
10/2008
1Phospholipids (Phosphatides)FDA LinkGeneric
02/2008
1tectochrysinIBA
06/2005
1FlavonoidsIBA
06/2005
16-prenylchrysinIBA
06/2005
1multidrug resistance-associated protein 1IBA
10/2004
1SesquiterpenesIBA
10/2004
1Acid PhosphataseIBA
06/2003

Therapy/Procedure

6Drug Therapy (Chemotherapy)
03/2016 - 10/2004
1Therapeutics
03/2011